Predictions of Protein Adsorption and Desorption in Liquid-Solid Circulating Fluidized Bed Ion Exchange System
نویسندگان
چکیده
The interest in recovery of various functional proteins from large volume of industrial broths and biological wastewater streams has increased in recent years, due to the advancement in genetic engineering, and concerns about recycling limited resources and environmental protection (Lan, 2001). Ion exchange adsorption and chromatography have long been used for downstream processing in the biotechnology industry because of its high binding capacity, high resolving power, and relatively inexpensive (Chang and Chase, 1996). As the protein concentration in the feedstock is fairly low, large volumes must be treated to recover proteins in an industrial scale. Therefore, a highly efficient continuous ion exchange process is necessary for the industrial scale protein purification.
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